14 Aug 2017

New Cannabis Tourist Town Being Made in California

Original article by Jennifer Kaplan, Bloomberg

Nipton, California

American Green Inc., a maker of cannabis products, is taking an unusual step to attract new customers as it capitalizes on California legalizing marijuana: It’s buying an entire town.

The company has acquired the tiny burg of Nipton, California, for about $5 million and plans to invest as much as $2.5 million over the next 18 months to create a pot-friendly tourist destination. The purchase includes 120 acres of land with a general store, a hotel, a school building and mineral baths.

American Green, based in Tempe, Arizona, will use the existing structures and build new ones powered by renewable energy ” to revitalize the town, said project manager Stephen Shearin..

The move shows how far marijuana has moved out of the shadows despite an uncertain federal policy outlook. With pot now legalized for recreational and medical use in California, Nevada and six other states, one in five American adults can consume the formerly taboo plant as they please. That’s created an opportunity for companies to try to make cannabis a more mainstream product.

Pamela Johnston, senior vice president at Electrum Partners, a cannabis industry advising and consulting firm, said restrictions on pot use and availability have limited tourism-related activities, but predicted it will be on par with other types of travel.

But before we blink, it will soon outpace other niche affinity travel  like wine, she said.

Nipton, with a population of about 20, is situated in California’s San Bernardino County next to the Mojave National Preserve and just across the border from Nevada. It’s about three hours by car from Los Angeles and just an hour from Las Vegas. Temperatures soar to more than 100 degrees Fahrenheit in the summer months. it used to be an old mining town.

American Green plans to include a new facility to manufacture water infused with CBD, the cannabis component that is typically associated with reducing pain and inflammation. The new Nipton will also have a production site for edible marijuana products, retail stores, and artist-in-residence programs

The Gold Rush built this city, Shearin said. The Green Rush can keep it moving the way people envisioned it years ago.



11 Aug 2017

CBD…What is it??

                        CBD molecule


CBD, which stands for cannabidiol (not cannabinoid), has become the new natural “it thing”. But what is it?

Cannabidiol was first discovered from the hemp plant in 1940 by chemist Roger Adams working at the University of Illinois. In 1963, scientists in Israel figured out its exact chemical structure.  Later research in the 1970s showed that CBD did not cause mental changes like THC,  but was mistakenly thought to be inactive. In the early 1990s the important discovery of the endocannabinoid system renewed interest in numerous phytocannabinoids. Over the past 15 years, hundreds of scientific articles researching how CBD interacts with the human brain and body have been published and the results are amazing!

CBDA, cannabidiolic acid, is the second most common phytocannabinoid produced in the cannabis plant ( the most common being THC). However,  CBDA is the most common phytocannabinoid in hemp, the fiber variety plant. CBDA, found in the raw cannabis flower, is converted to CBD when heated. CBD-rich plants were quite rare in the United States until around 2009, when reports of CBD’s therapeutic value surfaced. Cannabis growers began testing their plants for CBD and made efforts to stabilize CBD-rich varieties. There are now  a number of CBD-rich chemovars such as Charlotte’s Web, AC/DC, Cannatonic, Harlequin, Sour Tsunami, Blue Jay Way, and  others.

CBD Absorption and Metabolism

The bioavailability of CBD after inhalation is moderate, about 31%.  Unfortunately, CBD is absorbed poorly and erratically when taken by mouth. Sublingual absorption rates are low but less variable than oral ingestion. CBD is metabolized in the liver by enzymes in the P450 system. Most of this breakdown product is excreted in feces.

CBD Mechanism of Action

CBD does not bind to the cannabinoid receptor in the same fashion that THC does, which is why it is not intoxicating. CBD changes the way that THC binds to the cannabinoid receptor and blocks the conversion of THC to the more psychoactive 11-hydroxy-THC. CBD.  It also inhibits the reuptake of the endocannabinoid anandamide, thus enhancing the endocannabinoid system. CBD works at numerous non-cannabinoid receptors, such as the 5-HT1A (hydroxytryptamine) serotonin receptor, giving an antidepressant effect. It also works at the TRPV1 (vanilloid) receptor, giving analgesic and anti-inflammatory effects. CBD’s also influences the peroxisome proliferator activated receptors (PPARs) with multiple effects such as anti-proliferation of certain cancer cells, neuroprotection, and cardioprotection. CBD changes the way that GABA, an inhibitory neurotransmitter, binds to the GABA receptor, enhancing the calming, anti-anxiety effects of GABA. CBD also has been shown to reduce drug-seeking behavior and can have therapeutic effects on THC withdrawal and nicotine dependence.

Medicinal Properties of CBD

As you can see, CBD  works at many different places in the body, giving it numerous medicinal properties, which include:

Potent anti-inflammatory
Analgesic (pain reliever)
Anxiolytic (anti-anxiety)
Anti-cancer agent
CBD lessens the intoxicating effects of THC and reduces the adverse effects that some people experience with THC, namely rapid heartbeat, anxiety, and short-term memory loss. At the same time, when CBD is taken with THC to treat pain, the combination reduced pain more significantly than THC alone. In low doses, CBD is described as alerting, in high doses (>300 mg) it can be sedating.  Amazingly, CBD has very little side effects even at high doses.

Hemp CBD vs. Marijuana CBD

CBD is produced in both hemp/fiber variety and drug variety cannabis plants. They are the same compound, but we know from numerous studies that cannabinoids such as CBD work best when other cannabinoids and terpenoids are present, a synergy termed “the entourage effect.”  Hemp is virtually devoid of other cannabinoids and terpenoids. Also, industrial hemp contains very little CBD, necessitating a large number of hemp plants to obtain what can be obtained from one CBD-rich drug variety plant. The use of a large number of hemp plants also increases the risk of toxin contamination as hemp is a bio-accumulator, drawing up toxins from soil. (In fact: industrial hemp was planted around the Chernobyl nuclear power plant after the nuclear explosion in 1986). Most importantly, an excellent study from Israel in 2015 showed that whole-plant CBD, containing cannabinoids and terpenoids, was superior to single molecule CBD, with whole plant extract having a wider therapeutic window and better efficacy at lower doses. Thus, whole plant CBD-rich cannabis is more efficacious than hemp-based single molecule CBD.  

How Should Patients Choose Their CBD?

There are a small number of hemp products on the market that are labeled “hemp” to comply with governmental regulations that require these products to have less than 0.3% THC, but they are robust with cannabinoids and terpenoids. Other products have no cannabinoids including CBD, despite the manufacturers’ claims. In 2015 and 2016, the FDA purchased a number of CBD products online and tested them for the presence of CBD and other cannabinoids, finding that the amount of CBD claimed on the labels was markedly inaccurate — some products did not contain any CBD. In states that have medical cannabis laws, it’s best to obtain products from licensed suppliers who share their test results, which should confirm the product’s robust cannabinoid and terpenoid profiles.  If you are obtaining hemp through online outlets, thorough research is required as there are many false claims are being made.

CBD is truly an astouding compound! There are very few medicines that have such a long list of beneficial properties with little to no side effect and are completely natural. Many patients using CBD as medicine experience life-changing relief of symptoms and are able to discontinue ineffective and toxic medications. Unfortunately, CBD is still classified as a Schedule I federally illegal substance that is still prohibited from being thoroughly researched. We must be free to study this plant’s medicinal benefits to fully understand its impact on human health.

Reference Dr. Bonni Goldstein, https://www.marijuana.com/news/2017/07/know-your-medicine-cbd/

03 May 2017

Three Different Cannabinoid-Based Medicines Currently Approved by the FDA

"The U.S. Food and Drug Administration (FDA) is aware that cannabis and cannabis-derived products are being used for a number of medical conditions, such as AIDS wasting syndrome, epilepsy, neuropathic pain, and more. Despite this fact, the FDA has not yet approved a marketing application for a drug containing or derived from the whole cannabis plant. It has, however, approved three cannabinoid-based medicines derived from isolated synthetics: Marinol, Syndros, and Cesamet."Quote Text

From today's MedicalJane.com

The following comes from MedicalJane.com:

02 May 2017

Dr. Jacknin attends exciting 2017 World Medical Marijuana Business Convention & Expo in Pittsburgh

The Pittburgh conference put on by CompassionateCertificationCenters.com was one of the first in the country to offer Continuing Medical Education courses for physicians and nurses exclusively on cannabis, the endocannabinoid system, different cannabinoids and different applications. The speakers were fascinating…very advanced science and applications,. Loved it!

Dr. J., otherwise known as JJMD.