Summary for talk 10/11 Supply Side West Las Vegas

Ginkgo biloba is one of the oldest living tree species and its leaves are among the most extensively studied botanicals in use today. In Europe and the United States, ginkgo supplements are among the best-selling herbal medications. It consistently ranks as a top medicine prescribed in France and Germany.1

Ginkgo has been used in traditional medicine to treat circulatory disorders and enhance memory.   More than 40 components isolated from the ginkgo tree have been identified, but only two are believed to be responsible for the herb’s medicinal effects: flavonoids and terpenoids. Flavonoids are plant-based antioxidants. Antioxidants such as those found in ginkgo can help neutralize free radicals and may reduce or even help prevent some of the damage they cause, including aging of the skin. Terpenoids (such as ginkgolides) improve blood flow by dilating blood vessels and reducing the stickiness of platelets and are also potent antioxidants.1

Because Gingko biloba helps to increase circulation, prevent capillary fragility, and boosts collagen formation, it is ideal to use in rejuvenating skin care products. Gingko is a vasodilator, increases circulation, improves sebaceous secretions, decreases capillary hyper-permeability, improves tissue irrigation and activates cell metabolism in the skin. It also increases the creation of fibroblast, collagen and extracellular fibronectin, all required if you are looking to achieve a smooth and healthy young-looking complexion. In addition, Ginkgo exhibits good anti-oxidant, anti-inflammatory and anti-allergenic properties. 3

There have been many studies documenting the anti-inflammatory, anti-oxidant, and photoprotective properties of Ginkgo:

In 1992, Pietschmann performed two series of exams to determine the correlation between ultraviolet light load and oxidative stress as well as the way it is influenced by nutritive radical scavengers. Ginkgo was found to be the most effective natural ingredient tested in inhibiting the oxidative damage done by the UV light.8

Lin’s 1997 Taiwanese study of Ginkgo biloba extract (GBE) found that skin pretreated with 50% diluted GBE was protected from exacerbation of UVB damage. The GBE extract locally induced superoxide dismutase (SOD) and catalase (CAT) enzyme activity in the epidermis after topical application, thus increasing anti-oxidant activity and free radical protection.7

Hibatallah’s 1999 French study using in-vitro and in-vivo experiments confirmed the antioxidant properties of Ginkgo extract was equal to that of the control. 6

Bekerecioğlu‘s aim in his 1998 Turkish study was to show the role of free radical release into the tissue in the formation of skin necrosis, and to decrease the skin necrosis using various free radical scavengers. After inducing severe tissue necrosis, Bekerecioğlu studied Ginkgo balboa, pentoxifylline, alpha-tocopherol acetate, and alpha-tocopherol succinate treatment groups to prevent the necrosis.   The most effective agent to protect the skin against free radical damage was found to be the Ginkgo.10 In 1998 Bekerecioğlu also compared the effects of Gingko balboa extract (GBE), vitamin E, vitamin C, and deferoxamine on the prevention of dorsal flap skin necrosis in rats. The necrosed area of skin flaps were significantly reduced in the GBE group of 10 rats compared with the control group. This was thought due to GBE’s free radical scavenger activity. 11

In Aricioglu’s 2001 Turkish study, he investigated the effect of ginkgo biloba extract on UVB-irradiated skin by measuring the antioxidant enzyme superoxide dismutase (SOD) activity and Zinc levels in the skin, before and after treatment. After Ginkgo treatment, the SOD activity increased as compared with the untreated UVB irradiated group, as did the Zinc levels, in the same pattern as the SOD activity values.13

Belo’s 2011 study from Brazil assessed the photoprotective effects of topical formulations containing Gingko applied to the dorsal skin of hairless mice prior to UVA/B irradiation. After 20 hours, skin barrier damage, erythema, histological alterations and sunburn cell formation were evaluated. Formulations containing Ginkgo provided total protection of the skin barrier function avoiding UV radiation damage such as skin barrier damage and erythema. 5

Kim’s 1997 Korean study demonstrated the in vitro enhancing effects of Ginkgo extracts on the proliferation of the normal human skin fibroblast.   Increased production of collagen and extracellular fibronectin with Ginkgo extracts was also documented. 9

In 2010 a Thai study by Chuarienthong compared Ginkgo to tea and roobios in cosmetics. The ginkgo preparation increased skin moisturization by 28% and reduced wrinkles by 4% after 28 days.4

 

At least eight skin care lines already incorporate ginkgo into their anti-aging topical formulations for it’s proven anti-inflammatory, anti-oxidant and photoprotective effect.